Inter Milan were knocked out of the Europa League at the San Siro as Luka Jovic’s first half goal took Eintracht Frankfurt into the quarter-finals.
The 21-year-old Serbia forward raced clear to lob the ball over Inter keeper Samir Handanovic.
Inter, who were without Mauro Icardi, introduced 16-year-old Sebastiano Esposito, as they chased the game.
However, Frankfurt held on to reach their first quarter-final of a major European competition since 1994-95.
Luciano Spalletti’s Inter side currently reside in fourth position in Serie A, with Frankfurt in fifth position in the Bundesliga.
Meanwhile Slavia Prague shocked Sevilla to win 4-3 after extra-time and 6-5 on aggregate in a thrilling contest.
Napoli lost 3-1 to RB Salzburg in Austria but held on to progress to the quarter-finals 4-3 on aggregate.
Munas Dabbur, Fredrik Gulbrandsen and Christoph Leitgeb scored for last term’s semi-finalists but Arkadiusz Milik’s early goal proved decisive for the Serie A club.
Villareal ease through
In Spain, Villarreal progressed after a 2-1 victory over Zenit St Petersburg to complete a comfortable 5-2 aggregate win.
Gerard Moreno and Carlos Bacca scored for the hosts with former Chelsea defender Branislav Ivanovic pulling a goal back late on for the visitors.
Benfica overturned a 1-0 first-leg deficit against Dinamo Zagreb to advance after 3-1 on aggregate.
Substitute Jonas’ goal took the tie into extra-time before further goals from Ferro and Alejandro Grimaldo wrapped up their win.
Goncalo Guedes late goal saw Valencia reach the last eight after a 1-1 draw at FK Krasnodar.
Magomed Suleymanov’s 85th minute goal for the Russian club had looked as though it would take the tie into extra-time.